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Design and synthesis of two pyrazole libraries based ono-hydroxyacetophenones

✍ Scribed by José I. Borrell; Elisabeth Schuler; Jordi Teixidó; Enrique L. Michelotti

Book ID
111600751
Publisher
Springer
Year
2004
Tongue
English
Weight
234 KB
Volume
8
Category
Article
ISSN
1381-1991

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A series of novel pyrazole-based lipoprotein-associated phospholipase A 2 (Lp-PLA 2 ) inhibitors have been designed and synthetized by a variety of acetophenones via a 10-step convergent approach. The synthetic approach is carefully optimized, and an unsuccessful alternative route is also discussed.