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ChemInform Abstract: Design and Synthesis of Novel Pyrazole-Based Lp-PLA2 Inhibitors.

✍ Scribed by Yi Wang; Weiren Xu; Hua Shao; Yafei Xie; Jianwu Wang

Publisher
John Wiley and Sons
Year
2012
Weight
15 KB
Volume
43
Category
Article
ISSN
0931-7597

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πŸ“œ SIMILAR VOLUMES

Design and Synthesis of Novel Pyrazole-b
Design and Synthesis of Novel Pyrazole-based Lp-PLA2 Inhibitors
✍ Yi Wang; Weiren Xu; Hua Shao; Yafei Xie; Jianwu Wang πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 130 KB

A series of novel pyrazole-based lipoprotein-associated phospholipase A 2 (Lp-PLA 2 ) inhibitors have been designed and synthetized by a variety of acetophenones via a 10-step convergent approach. The synthetic approach is carefully optimized, and an unsuccessful alternative route is also discussed.