Synthesis of 2-substituted d-tryptophan-
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Takehiro Fukami; Takeru Yamakawa; Hisaki Kojima; Yuuka Amano; Masaki Ihara; Mits
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Article
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1995
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Elsevier Science
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English
β 347 KB
Peptide derivatives with 2-substituted D-tryptophan analogues were synthesized. All prepared peptide derivatives showed potent affinity for ETa receptors, while their ETA affinity depended on the substituents of the D-tryptophanyl residue. A 2-bromo-D-tryptophan derivative 16b (BQ-928) was a combine