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Design and synthesis of tryptophan containing dipeptide derivatives as formyl peptide receptor 1 antagonist

✍ Scribed by Hwang, Tsong-Long; Hung, Chih-Hao; Hsu, Ching-Yun; Huang, Yin-Ting; Tsai, Yu-Chi; Hsieh, Pei-Wen


Book ID
120327498
Publisher
Royal Society of Chemistry
Year
2013
Tongue
English
Weight
330 KB
Volume
11
Category
Article
ISSN
1477-0520

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Synthesis of 2-substituted d-tryptophan-
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Peptide derivatives with 2-substituted D-tryptophan analogues were synthesized. All prepared peptide derivatives showed potent affinity for ETa receptors, while their ETA affinity depended on the substituents of the D-tryptophanyl residue. A 2-bromo-D-tryptophan derivative 16b (BQ-928) was a combine