✦ LIBER ✦

Design and synthesis of potent carboxylic acid DGAT1 inhibitors with high cell permeability

✍ Scribed by Ustav Bali; Oscar Barba; Graham Dawson; William T. Gattrell; James G. Horswill; David A. Pan; Martin J. Procter; Chrystelle M. Rasamison; Colin P. Sambrook Smith; Amanda Taylor-Warne; Philippe Wong-Kai-In

Book ID: 113496494
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 532 KB
Volume: 22
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2011.12.050

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Design and synthesis of potent β-secreta

Design and synthesis of potent β-secretase (BACE1) inhibitors with carboxylic acid bioisosteres

✍ Tooru Kimura; Yoshio Hamada; Monika Stochaj; Hayato Ikari; Ayaka Nagamine; Hamdy 📂 Article 📅 2006 🏛 Elsevier Science 🌐 English ⚖ 391 KB

Design and Synthesis of Potent β-Secreta

Design and Synthesis of Potent β-Secretase (BACE1) Inhibitors with P′1 Carboxylic Acid Bioisosteres.

✍ Yoshiaki Kiso; et al. et al. 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 12 KB 👁 1 views

Discovery of a Potent and Selective DGAT

Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety

✍ He, Shuwen; Hong, Qingmei; Lai, Zhong; Yang, David X.; Ting, Pauline C.; Kuethe, 📂 Article 📅 2014 🏛 American Chemical Society 🌐 English ⚖ 615 KB

Design and synthesis of potent, orally-a

Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3-d]pyrimidine core

✍ Robert L. Dow; Melissa Andrews; Gary E. Aspnes; Gayatri Balan; E. Michael Gibbs; 📂 Article 📅 2011 🏛 Elsevier Science 🌐 English ⚖ 477 KB

ChemInform Abstract: Design and Synthesi

ChemInform Abstract: Design and Synthesis of Potent, Orally-Active DGAT-1 Inhibitors Containing a Dioxino[2,3-d]pyrimidine Core.

✍ Robert L. Dow; et al. et al. 📂 Article 📅 2012 🏛 John Wiley and Sons ⚖ 16 KB 👁 1 views

Structure-Based Design of Potent and Sel

Structure-Based Design of Potent and Selective Cell-Permeable Inhibitors of Human β-Secretase (BACE-1)

✍ Stachel, Shawn J.; Coburn, Craig A.; Steele, Thomas G.; Jones, Kristen G.; Loutz 📂 Article 📅 2004 🏛 American Chemical Society 🌐 English ⚖ 25 KB