Toward nonpeptidal substance P mimetic a
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Michael Chorev; Eli Roubini; Chaim Gilon; Zvi Selincer
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Article
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1991
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Wiley (John Wiley & Sons)
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English
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## SYNOPSIS 1,4-Piperazine and 4-hydroxy proline, two small cyclic polyfunctional systems with defined stereochemistry, were introduced as "molecular scaffolds." We define a "bioactive topology," which is a derived putative low-energy conformation obtained through theoretical conformational analys