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Design and synthesis of immobilized Tamiflu analog on resin for affinity chromatography

โœ Scribed by Yasuaki Kimura; Kenzo Yamatsugu; Motomu Kanai; Noriko Echigo; Takashi Kuzuhara; Masakatsu Shibasaki

Book ID
104096252
Publisher
Elsevier Science
Year
2009
Tongue
French
Weight
430 KB
Volume
50
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

A resin linked with the Tamiflu core was synthesized by modifying our original synthetic route of oseltamivir phosphate (Tamiflu). The prepared resin bound to the influenza virus enzyme neuraminidase, the main target of Tamiflu. The immobilized Tamiflu analog will be useful for isolating and identifying presumed endogenous vertebrate proteins that interact with Tamiflu, which might relate to the abnormal behavior exhibited by some influenza patients treated with Tamiflu.

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