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Design and Synthesis of Histidine Analogues of Folic Acid and Methotrexate as Potential Folylpolyglutamate Synthetase Inhibitors

โœ Scribed by Mao, Zhenmin; Pan, Jianping; Kalman, Thomas I.


Book ID
126265530
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
251 KB
Volume
39
Category
Article
ISSN
0022-2623

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Dethiobiotin synthetase (DTBS ; E.C. 6.6.6.6), the penultimate enzyme in the biosynthesis of the essential vitamin biotin, is a new potential target for novel herbicides. Inhibitors were designed based on mechanistic and structural information. The in-vitro activities of these potential inhibitors v