ChemInform Abstract: Synthesis of ATP Analogues as Potential Glutamine Synthetase Inhibitors.
β Scribed by Sheriff Salisu; Colin Kenyon; Perry T. Kaye
- Publisher
- John Wiley and Sons
- Year
- 2011
- Weight
- 28 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Abstract
A preliminary study toward the synthesis of both adenine and allopurinol derivatives as novel ATP analogues or scaffolds for the construction of such analogues is reported.
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Dethiobiotin synthetase (DTBS ; E.C. 6.6.6.6), the penultimate enzyme in the biosynthesis of the essential vitamin biotin, is a new potential target for novel herbicides. Inhibitors were designed based on mechanistic and structural information. The in-vitro activities of these potential inhibitors v