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Design and Synthesis of Estrarubicin: a Novel Class of Estrogen-Anthracenedione Hybrids

✍ Scribed by Francesco De Riccardis; Daniela Meo; Irene Izzo; Marcello Di Filippo; Agostino Casapullo

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
369 KB
Volume
1998
Category
Article
ISSN
1434-193X

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✦ Synopsis

The synthesis of estrarubicin, a member of a new class of LiClO 4 in diethyl ether, revealed notable diastereofacial selectivity of the diene, leading mainly to cycloadduct 8. estrogen-anthraquinone hybrids, has been accomplished in an 8-step sequence starting from estrone. The octacyclic Elaboration of the dihydroxyanthraquinone moiety and highly stereoselective epoxidation of the βˆ† 17(20) bond yielded carbon skeleton has been elaborated by a Diels-Alder reaction using diene 5 and known epoxy-tetrone 6 as estrarubicin 2. precursors. The cycloaddition reaction, performed in 5 M

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ChemInform Abstract: Design and Synthesi
ChemInform Abstract: Design and Synthesis of Estrarubicin: A Novel Class of Estrogen-Anthracenedione Hybrids.
✍ F. DE RICCARDIS; D. MEO; I. IZZO; M. DI FILIPPO; A. CASAPULLO πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 33 KB πŸ‘ 1 views

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