Design and synthesis of cationic Aib-containing antimicrobial peptides: conformational and biological studies
โ Scribed by Sofia Zikou; Anna-Irini Koukkou; Panorea Mastora; Maria Sakarellos-Daitsiotis; Constantinos Sakarellos; Constantin Drainas; Eygenia Panou-Pomonis
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 151 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1075-2617
- DOI
- 10.1002/psc.876
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๐ SIMILAR VOLUMES
Analogues of alamethicin, a 20-mer amphipathic helical peptide with ionophore activity, in the sequence of which all Aib residues were substituted by Ala (Al) or Leu (Ll), were synthesized by the solid phase method, purified by high performance liquid chromatography and characterized by fast atomic
The protected poly-Aib oligopeptides Z-(Aib) n -N(Me)Ph with n ยผ 2 -6 were prepared according to the azirine/oxazolone method, i.e., by coupling amino or peptide acids with 2,2,N-trimethyl-N-phenyl-2H-azirin-3-amine (1a) as an Aib synthon (Scheme 2). Following the same concept, the segments Z-(Aib)
## Abstract Two trisโalkoxycarbonyl homoarginine derivatives, BocโHar{ฯ,ฯโฒโ[Z(2Br)]~2~}โOH and BocโHar{ฯ,ฯโฒโ[Z(2Cl)]~2~}โOH, were prepared by guanidinylation of BocโLysโOH, and used for the synthesis of neoโendorphins and dynorphins. The results were compared with that obtained in the synthesis in