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Design and synthesis of a potent and specific renin inhibitor with a prolonged duration of action in vivo

✍ Scribed by Thaisrivongs, Suvit; Pals, Donald T.; Harris, Douglas W.; Kati, Warren M.; Turner, Steve R.


Book ID
126482257
Publisher
American Chemical Society
Year
1986
Tongue
English
Weight
869 KB
Volume
29
Category
Article
ISSN
0022-2623

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## Abstract A highly potent renin inhibitor of the azapeptide type (2) is synthesized by starting from the hydrazine derivative 3. This peptide analogue inhibits renin in the same range (nanomolar) as its purely peptidic original 2a, but reveals much higher specificity for renin than 2a does.