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Design and Synthesis of 4,5-Diphenyl-4-isoxazolines: Novel Inhibitors of Cyclooxygenase-2 with Analgesic and Antiinflammatory Activity

โœ Scribed by Habeeb, Amgad G.; Praveen Rao, P. N.; Knaus, Edward E.

Book ID
120029913
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
183 KB
Volume
44
Category
Article
ISSN
0022-2623

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Design and syntheses of methyl 2-methyl-2-[2-(4-benzoyl-5-phenyl-7-halo-2-azabicyclo[4.1.0]hept-3-ene)]acetates: novel inhibitors of cyclooxygenase-2 (COX-2) with analgesic-antiinflammatory activity
โœ Sammy Agudoawu; Huiying Li; Amgad G. Habeeb; P.N. Praveen Rao; Mavanur R. Suresh ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 194 KB ๐Ÿ‘ 1 views

A group of methyl 2-methyl-2- [2-(4-benzoyl-5-phenyl-7-halo-2-azabicyclo[4.1.0]hept-3ene)]acetates (1015), and the related acetamide derivative ( 16), that possess a variety of C-7 substituents (Br, Cl, F, H), were designed for evaluation as analgesic-antiinflammatory agents. The effect of the C-7 s