Large quantities of an enantiomerically pure novel dual PPARa/c agonist were required. Three routes were successfully developed to achieve this goal, with the chosen route utilized to deliver 40 g of material.
Design and Synthesis of 2-Methyl-2-{4-[2-(5-methyl-2-aryloxazol- 4-yl)ethoxy]phenoxy}propionic Acids: A New Class of Dual PPARα/γ Agonists
✍ Scribed by Brooks, Dawn A.; Etgen, Garret J.; Rito, Christopher J.; Shuker, Anthony J.; Dominianni, Samuel J.; Warshawsky, Alan M.; Ardecky, Robert; Paterniti, James R.; Tyhonas, John; Karanewsky, Donald S.; Kauffman, Raymond F.; Broderick, Carol L.; Oldham, Brian A.; Montrose-Rafizadeh, Chahzrad; Winneroski, Leonard L.; Faul, Margaret M.; McCarthy, James R.
- Book ID
- 120012632
- Publisher
- American Chemical Society
- Year
- 2001
- Tongue
- English
- Weight
- 63 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0022-2623
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