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Design and novel synthesis of aryl-heteroaryl-imidazole MAP kinase inhibitors

✍ Scribed by Markus R Dobler

Book ID
104254386
Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
180 KB
Volume
44
Category
Article
ISSN
0040-4039

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✦ Synopsis

Inhibitors of the MAP kinase p38, potentially useful for the treatment of rheumatoid arthritis and inflammatory diseases, were found to exhibit antifungal activity. We have developed a new diversity-oriented strategy leading to concise and efficient syntheses of known and new members of this compound class. The strategy is based on carbon carbon cross-coupling reactions using N-protected 4,5-diiodo-imidazoles as the starting templates.

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