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Design and Evolution of a Miniature Bcl-2 Binding Protein

โœ Scribed by Jason W. Chin; Alanna Schepartz

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
226 KB
Volume
40
Category
Article
ISSN
0044-8249

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โœฆ Synopsis

A major challenge for chemical biologists lies in the design of potent and selective ligands for protein surfaces. Here a protein grafting and evolution strategy is used to discover highly potent and specific miniature protein ligands for human Bcl-2 and Bcl-X . Miniature proteins could be used to dissect, modulate, or analyze a single protein function, irrespective of the other functions the protein may regulate within the proteome.

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