Design of a Conformation-Sensitive Xenon-Binding Cavity in the Ribose-Binding Protein
โ Scribed by Thomas J. Lowery; Seth M. Rubin; E. Janette Ruiz; Alexander Pines; David E. Wemmer
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 170 KB
- Volume
- 116
- Category
- Article
- ISSN
- 0044-8249
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๐ SIMILAR VOLUMES
## Abstract It is an accepted practice in ligand design to introduce conformational constraint with the expectation of improving affinity, justified by the theoretical possibility that an unfavorable change in binding entropy will be reduced. This rationale of minimizing the entropic penalty throug
## Abstract Highly purified riboseโbinding protein from Escherichia coli has been used to reconstitute a bindingโproteinโdependent ribose transport in spheroplasts derived from a bindingโproteinโdeficient mutant of E coli K 12, and in spheroplasts derived from Salmonella typhimurium. The crossโspec