𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Design and development of selective muscarinic agonists for the treatment of Alzheimer's disease: characterization of tetrahydropyrimidine derivatives and development of new approaches for improved affinity and selectivity for M1 receptors

✍ Scribed by William S. Messer Jr.; W.G. Rajeswaran; Yang Cao; Hai-Jun Zhang; Afif A. El-Assadi; Colleen Dockery; Jill Liske; John O'Brien; Frederick E. Williams; Xi-Ping Huang; Mary E. Wroblewski; Peter I. Nagy; Steven M. Peseckis


Book ID
114074278
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
143 KB
Volume
74
Category
Article
ISSN
0031-6865

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Development of M1 subtype selective musc
✍ R.D. Schwarz; M.J. Callahan; R.E. Davis; J.C. Jaen; H. Tecle πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 131 KB πŸ‘ 2 views

Clinical trials in Alzheimer's disease (AD) with first generation muscarinic agonists (e.g., arecoline, oxotremorine, pilocarpine) produced inconsistent results due to poor pharmacokinetic properties and a lack of separation between central and peripheral activities observed with these compounds. Se

[Pharmacochemistry Library] Receptor Che
✍ Messer, William S. πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier 🌐 English βš– 665 KB

*Receptor Chemistry Towards the Third Millennium* is the result of papers presented at the 12th Camerino-Noordwijkerhout Symposium, held in Camerino, Italy in September 1999. Although much is known about the way ligands interact with receptors, which have now been isolated, characterized and cloned,

Development of CDD-0102 as a selective M
✍ William S. Messer Jr.; Kenneth A. Bachmann; Colleen Dockery; Afif A. El-Assadi; πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 289 KB πŸ‘ 1 views

## Abstract Selective muscarinic agonists might be useful in the treatment of Alzheimer's disease. To help characterize the activity and functional selectivity of two M~1~ muscarinic agonists, secretion of amyloid precursor protein, brain penetration, side effect profiles, cognition‐enhancing prope