Clinical trials in Alzheimer's disease (AD) with first generation muscarinic agonists (e.g., arecoline, oxotremorine, pilocarpine) produced inconsistent results due to poor pharmacokinetic properties and a lack of separation between central and peripheral activities observed with these compounds. Se
Design and development of selective muscarinic agonists for the treatment of Alzheimer's disease: characterization of tetrahydropyrimidine derivatives and development of new approaches for improved affinity and selectivity for M1 receptors
β Scribed by William S. Messer Jr.; W.G. Rajeswaran; Yang Cao; Hai-Jun Zhang; Afif A. El-Assadi; Colleen Dockery; Jill Liske; John O'Brien; Frederick E. Williams; Xi-Ping Huang; Mary E. Wroblewski; Peter I. Nagy; Steven M. Peseckis
- Book ID
- 114074278
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 143 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0031-6865
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## Abstract Selective muscarinic agonists might be useful in the treatment of Alzheimer's disease. To help characterize the activity and functional selectivity of two M~1~ muscarinic agonists, secretion of amyloid precursor protein, brain penetration, side effect profiles, cognitionβenhancing prope