✦ LIBER ✦

Use of an M1/M4-selective muscarinic agonist in combination with a peripheral antagonist as a novel approach for the treatment of Alzheimer's disease

✍ Scribed by Hanson, Seth A.; Verdone, Melinda L.; Hendrickson, Michael L.; Ockuly, Jeffrey C.; Beck, Joseph D.; Albers, Andrea M.; Farnham, James G.; Abraham, Brent D.; Copp, Richard R.; Twose, Trevor M.

Book ID: 123280323
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 40 KB
Volume: 6
Category: Article
ISSN: 1552-5260
DOI: 10.1016/j.jalz.2010.05.1893

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Development of CDD-0102 as a selective M

Development of CDD-0102 as a selective M1 agonist for the treatment of Alzheimer's disease

✍ William S. Messer Jr.; Kenneth A. Bachmann; Colleen Dockery; Afif A. El-Assadi; 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 289 KB 👁 1 views

## Abstract Selective muscarinic agonists might be useful in the treatment of Alzheimer's disease. To help characterize the activity and functional selectivity of two M~1~ muscarinic agonists, secretion of amyloid precursor protein, brain penetration, side effect profiles, cognition‐enhancing prope

An M1 selective agonist AF102b, as a pot

An M1 selective agonist AF102b, as a potential drug in treatment of Alzheimer's disease: Biochemical and pharmacological properties

✍ R. Haring; N. Eshhar; E. Heldman; D. Marciano; Y. Kloog; A. Fisher 📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 109 KB

P4-305: Allosteric potentiation of the M

P4-305: Allosteric potentiation of the M1 muscarinic receptor provides unprecedented selectivity and a novel therapeutic strategy for the treatment of Alzheimer's disease

✍ Ray, William J.; Seager, Matthew; Ma, Lei; Wittmann, Marion; Getty, Krista; Marl 📂 Article 📅 2008 🏛 Elsevier Science 🌐 English ⚖ 52 KB

The selective muscarinic M1 agonist AF10

The selective muscarinic M1 agonist AF102B decreases levels of total Aβ in cerebrospinal fluid of patients with Alzheimer's disease

✍ Roger M. Nitsch; Meihua Deng; Marsha Tennis; David Schoenfeld; John H. Growdon 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 124 KB 👁 1 views

Sensitive liquid chromatographic method

Sensitive liquid chromatographic method for the determination of a specific M1 agonist, LY246708, an investigational agent with potential for the treatment of Alzheimer's disease, in human plasma

✍ Cristi L. Hamilton; Jeffrey A. Kirkwood; Guy Carter; Richard S. Williams 📂 Article 📅 1993 🏛 Elsevier Science ⚖ 438 KB

Extent of disease as an indication for p

Extent of disease as an indication for pelvic radiation fallowing radical hysterectomy and bilateral pelvic lymph node dissection in the treatment of stage IB and IIA cervical carcinoma: Monk B.J.; Cha D.-S.; Walker J.L.; Burger R.A.; Ramsinghani N.S.; Manetta A.; DiSaia P.J.; Berman M.L. USA Gynecol Oncol 1994 54/1 (4–9)

📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 250 KB