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Design and concise synthesis of gem-difluoromethylenated analogue of 7-epi-castanospermine

โœ Scribed by Jiang, Xin-Yi; Xu, Xiu-Hua; Qing, Feng-Ling


Book ID
122907699
Publisher
Chinese Electronic Periodical Services
Year
2014
Tongue
English
Weight
833 KB
Volume
25
Category
Article
ISSN
1001-8417

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โœ C.-Kuan Lee; K.Y. Sim; Jun Zhu ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 309 KB

Trihydroxyindolizidine (1) and its (7R)-deoxyfh~on~ analogue (2) was synthesised from 5,8-benzyloxycarbonylimino-5.6,7,8-tetradeoxy-l,2-0-isopropylidene-a-D-gluco-octose (3). The key step is an oxidation-reduction sequence. Introduction of a fluoro substituent at C-3 (6) was readily effected by disp