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Desensitization of adenosine A1 receptors in rat immature cortical neurons

✍ Scribed by María Ángeles Ruiz; David Agustín León; José Luis Albasanz; Mairena Martín

Book ID
113589523
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
594 KB
Volume
670
Category
Article
ISSN
0014-2999

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## Abstract The expression of adenosine A~1~ receptors was investigated using [^3^H]2‐chloro‐N^6^ ‐cyclopentyladenosine (CCPA) in 8‐day‐old cultured neurons from fetal rat forebrain grown in serum‐free medium. [^3^H]CCPA bound specifically and with high affinity (Kd = 2.9 nM) to a homogeneous popul