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Desensitization and muscarinic re-sensitization of force and myosin light chain phosphorylation to cytoplasmic Ca2+ in smooth muscle

โœ Scribed by Toshio Kitazawa; Andrew P. Somlyo

Book ID
115763412
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
458 KB
Volume
172
Category
Article
ISSN
0006-291X

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Effects of a myosin light chain kinase i
Effects of a myosin light chain kinase inhibitor, wortmannin, on cytoplasmic Ca2+levels, myosin light chain phosphorylation and force in vascular smooth muscle
โœ Makoto Takayama; Hiroshi Ozaki; Hideaki Karaki ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Springer-Verlag ๐ŸŒ English โš– 870 KB

Biochemical studies have shown that wortmannin is an inhibitor of myosin light chain (MLC) kinase (Nakanishi et al. (1992) J. Biol. Chem. 267: 2157-2163). To investigate the role of MLC kinase in smooth muscle contractions, we examined the effects of wortmannin on isolated smooth muscles of the rat