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Description and prediction of peptide-MHC binding: the ‘human MHC project’

✍ Scribed by Søren Buus

Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
686 KB
Volume
11
Category
Article
ISSN
0952-7915

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✦ Synopsis

and prediction of peptide-MHC binding: the 'human MHC project' G-en Buus MHC molecules are crucially involved in controlling the specific immune system. They are highly polymorphic receptors sampling peptides from the cellular environment and presenting these peptides for scrutiny by immune cells. Recent advances in combinatorial peptide chemistry have improved the description and prediction of peptide-MHC binding.

It is envisioned that a complete mapping of human immune reactivities will be possible.

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✍ Hiroshi Mamitsuka 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 186 KB 👁 2 views

The binding of a major histocompatibility complex (MHC) molecule to a peptide originating in an antigen is essential to recognizing antigens in immune systems, and it has proved to be important to use computers to predict the peptides that will bind to an MHC molecule. The purpose of this paper is t