Linkage a n a l y s i s i n a f f e c t e d f a m i l i e s i n d i c a t e s a h i g h frequency of recombination around t h i s s i t e i n some f a m i l i e s , a l t h o u g h i n o t h e r s t h e g e n e t i c r e l a t i o n s h i p s a r e q u i t e d i f f e r e n t and c l o s e r l i n k
Dermatoglyphic peculiarities in families with X-linked mental retardation and fragile site Xq27: a collaborative study
β Scribed by A. Rodewald; U. Froster-Iskenius; E. Kab; U. Langenbeck; A. Schinzel; A. Schmidt; E. Schwinger; P. Steinbach; H. Veenema; R.-D. Wegner; A. Wirtz; H. Zankl; M. Zankl
- Book ID
- 115089383
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 729 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0009-9163
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π SIMILAR VOLUMES
Data are presented suggesting that the form of X-linked mental retardation with macro-orchidism and the form associated with a fragile site at Xq27 or 28 are the same entity.
We report an extended family in which two brothers with a fragile X chromosome are mentally retarded while a third brother with the fragile site is both phenotypically and mentally normal. The study of six probes detecting restriction fragment length polymorphisms on either sides of the fragile site