𝔖 Bobbio Scriptorium
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Dermatitis from idoxuridine

✍ Scribed by N. Balato; P. Nappa; G. Lembo; F. Ayala


Book ID
109368376
Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
204 KB
Volume
13
Category
Article
ISSN
0105-1873

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Data are presented for the hydrolytic degradation of idoxuridine (5-iodo-2 '-deoxyuridine) in aqueous solution over a wide range of hydrogen ion concentration (pH 1.3 to 12.0). The over-all reaction rate was experimentally equal to R, '' K, + IH+l idoxuridine at p H 6.0 was found to be approximately

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Data are presented to show that the rincipal decomposition products of idoxuricfke ophthalmic solution in acidic media (PH 1.3 to 6.7) are 5-iodouracil and 2-deoxyribose. A trace of Z'-deoxyuridine was also detected. Uracil was not formed under the conditions of these experiments.