Derivatives of N-alkyl(aryl)-1,2(1,3)-diazacycloalkanes. Antimicrobial properties
β Scribed by V. M. Farzaliev; G. B. Babaeva; M. T. Abbasova; O. G. Nabiev; Z. K. Soltanova; Ya. M. Kerimova
- Publisher
- Springer US
- Year
- 2009
- Tongue
- English
- Weight
- 450 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0009-3092
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Substituted tetrahydroisoquinolines are synthesized in optically pure form using a Grignard reaction of N,N-dibenzyl aminol and Friedel-Crafts cyclization as the key steps.
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## Abstract magnified image Cyclocondensation of 2βacylphenylacetonitriles **1** with amines affords 1βsubstituted 3βaminoisoquinolines **2** in good yields.