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Highly efficient synthesis of 3-alkyl/aryl-4-aryl-1,2,3,4-tetrahydroisoquinolines from N,N-dibenzylaminols

✍ Scribed by S Chandrasekhar; N.Ramakrishna Reddy; M.Venkat Reddy; B Jagannadh; A Nagaraju; A Ravi Sankar; A.C Kunwar

Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 142 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)00130-2

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✦ Synopsis

Substituted tetrahydroisoquinolines are synthesized in optically pure form using a Grignard reaction of N,N-dibenzyl aminol and Friedel-Crafts cyclization as the key steps.

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