Derivation of Dihedral Angles from CH–CH Dipolar–Dipolar Cross-Correlated Relaxation Rates: A C–C Torsion Involving a Quaternary Carbon Atom in Epothilone A Bound to Tubulin

✍ Scribed by Teresa Carlomagno; Víctor M. Sánchez; Marcel J. J. Blommers; Christian Griesinger

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 132 KB
• Volume: 115
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/ange.200350950

✦ Synopsis

Cross-correlated relaxation (CCR) rates constitute a valid alternative to coupling constants for the determination of dihedral angles. [1] For high-molecular-weight systems the measurement of scalar coupling constants poses serious problems caused by large linewidths and by differential relaxation effects. [2] Conversely, CCR measurements are feasible also for molecules of large size and have been successfully employed in the past years to determine dihedral angles in biomolecules. [3][4][5][6] We have recently reported the usage of cross-correlated relaxation rates to derive angular

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