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Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice

✍ Scribed by Giorgio Cattoretti; Laura Pasqualucci; Gianna Ballon; Wayne Tam; Subhadra V. Nandula; Qiong Shen; Tongwei Mo; Vundavalli V. Murty; Riccardo Dalla-Favera


Book ID
113523555
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
785 KB
Volume
7
Category
Article
ISSN
1535-6108

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Bcl-6 (LAZ-3) and Bcl-2 gene rearrangements have been respectively reported in 20-35 per cent and 10-25 per cent of diffuse large B-cell lymphomas (DLBCLs). Although these genetic lesions have been associated with different clinical outcomes (i.e., more favourable in Bcl-6 rearranged cases and poore