Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice
β Scribed by Giorgio Cattoretti; Laura Pasqualucci; Gianna Ballon; Wayne Tam; Subhadra V. Nandula; Qiong Shen; Tongwei Mo; Vundavalli V. Murty; Riccardo Dalla-Favera
- Book ID
- 113523555
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 785 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1535-6108
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## Abstract ## BACKGROUND In Western populations, rearrangement of the __BCL__β6 gene can be identified in 20β40% of patients with diffuse large Bβcell lymphoma (DLBCL). Analysis of the __BCL__β6 gene has revealed the presence of point mutations or small deletions in 70% of DLBCL tumors; however,
Bcl-6 (LAZ-3) and Bcl-2 gene rearrangements have been respectively reported in 20-35 per cent and 10-25 per cent of diffuse large B-cell lymphomas (DLBCLs). Although these genetic lesions have been associated with different clinical outcomes (i.e., more favourable in Bcl-6 rearranged cases and poore