Clinical relevance of CD10, BCL-6 and multiple myeloma-1 expression in diffuse large B-cell lymphomas in Malaysia
β Scribed by Suat-Cheng Peh; Gin-Gin Gan; Lin-Kiat Lee; Geok-Im Eow
- Book ID
- 115175964
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 354 KB
- Volume
- 58
- Category
- Article
- ISSN
- 1320-5463
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Bcl-6 (LAZ-3) and Bcl-2 gene rearrangements have been respectively reported in 20-35 per cent and 10-25 per cent of diffuse large B-cell lymphomas (DLBCLs). Although these genetic lesions have been associated with different clinical outcomes (i.e., more favourable in Bcl-6 rearranged cases and poore
## Abstract ## BACKGROUND In Western populations, rearrangement of the __BCL__β6 gene can be identified in 20β40% of patients with diffuse large Bβcell lymphoma (DLBCL). Analysis of the __BCL__β6 gene has revealed the presence of point mutations or small deletions in 70% of DLBCL tumors; however,
## Abstract bclβ6, CD10 and CD38 are useful markers for identifying 2 molecularly and prognostically distinct profiles of diffuse large Bβcell lymphomas (LCLs), defined as germinalβcenter Bβlike and activated Bβlike. We investigated the prognostic role of bclβ6, CD10 and CD38 immunoreactivity in 10