Dequalinium induces cell death in human leukemia cells by early mitochondrial alterations which enhance ROS production

✍ Scribed by Pilar Sancho; Eva Galeano; Elena Nieto; M. Dolores Delgado; Ana Isabel García-Pérez

• Book ID: 104040326
• Publisher: Elsevier Science
• Year: 2007
• Tongue: English
• Weight: 732 KB
• Volume: 31
• Category: Article
• ISSN: 0145-2126
• DOI: 10.1016/j.leukres.2006.11.018

✦ Synopsis

Dequalinium (DQA) has been proposed as a selective antitumoral agent due to its preferential accumulation in mitochondria of cancer cells. Our aim was a better understanding of DQA cytotoxicity. DQA-induced NB4 and K562 cell alterations are initiated within the first 30 min of treatment at a high DQA concentration with a mitochondrial membrane depolarization. Cytochrome c release to cytoplasm, superoxide anion overproduction and ATP depletion in NB4 cells induce, 16 h later, apoptosis by a typical caspase-9/caspase-3-dependent intrinsic pathway. K562 cells were more resistant to the DQA effect than NB4 cells, remaining viable for longer time periods.