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Rotenone induces cell death in primary dopaminergic culture by increasing ROS production and inhibiting mitochondrial respiration

✍ Scribed by Khaled Radad; Wolf-Dieter Rausch; Gabriele Gille


Book ID
116764833
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
454 KB
Volume
49
Category
Article
ISSN
0197-0186

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Proteasomal dysfunction has been implicated in neurodegenerative disorders and during aging processes. In frontotemporal dementias, corticobasal degeneration, and progressive supranuclear palsy, oligodendrocytes are specifically damaged. Application of proteasomal inhibitors to cultured oligodendroc