Proteasome inhibition by MG-132 induces
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Olaf Goldbaum; Grit Vollmer; Christiane Richter-Landsberg
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Article
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2006
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John Wiley and Sons
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English
β 713 KB
Proteasomal dysfunction has been implicated in neurodegenerative disorders and during aging processes. In frontotemporal dementias, corticobasal degeneration, and progressive supranuclear palsy, oligodendrocytes are specifically damaged. Application of proteasomal inhibitors to cultured oligodendroc