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Depression of plasma lipids in the rat by orotic acid and its reversal by adenine

✍ Scribed by H.G. Windmueller

Book ID: 118848167
Publisher: Elsevier Science
Year: 1963
Tongue: English
Weight: 235 KB
Volume: 11
Category: Article
ISSN: 0006-291X
DOI: 10.1016/0006-291x(63)90099-8

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Our earlier studies have shown that in normal hepatocytes, orotic acid (OA) inhibits DNA synthesis induced by several growth factors in vitro and after two-thirds partial hepatectomy (PH) in vivo. As in the normal liver OA induces an imbalance in nucleotide pools (specifically, an increase in uridin