The regulation of ribonucleoside diphosp
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Sharmila Manjeshwar; Prema M. Rao; Srinivasan Rajalakshmi; Dittakavi S.R. Sarma
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Article
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1999
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John Wiley and Sons
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English
⚖ 159 KB
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Our earlier studies have shown that in normal hepatocytes, orotic acid (OA) inhibits DNA synthesis induced by several growth factors in vitro and after two-thirds partial hepatectomy (PH) in vivo. As in the normal liver OA induces an imbalance in nucleotide pools (specifically, an increase in uridin