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Improvement of the energy supply and contractile function in normal and ischemic rat hearts by dietary orotic acid

✍ Scribed by Laura Cristina Jardim Pôrto; Carlos Henrique de Castro; Sílvia Silveira Quintão Savergnini; Sérgio Henrique Sousa Santos; Adaliene Versiani Matos Ferreira; Letícia Maria de Souza Cordeiro; Deny Bruce de Sousa Sobrinho; Robson Augusto Souza Santos; Alvair Pinto de Almeida; Leida Maria Botion


Book ID
116720128
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
844 KB
Volume
90
Category
Article
ISSN
0024-3205

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Our earlier studies have shown that in normal hepatocytes, orotic acid (OA) inhibits DNA synthesis induced by several growth factors in vitro and after two-thirds partial hepatectomy (PH) in vivo. As in the normal liver OA induces an imbalance in nucleotide pools (specifically, an increase in uridin