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Depression of cytochrome P-450-dependent drug biotransformation by adriamycin

✍ Scribed by Deborah J. Marchand; Kenneth W. Renton


Book ID
113205583
Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
428 KB
Volume
58
Category
Article
ISSN
0041-008X

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## Objectives: The biotransformation of caffeine has been studied in vitro using human cytochrome p-450 isoenzymes (cyps) expressed in human b-lymphoblastoid cell lines, namely cyp1a1, 1a2, 2a6, 2b6, 2d6-val, 2e1 and 3a4, and microsomal epoxide hydroxylase (eh). in addition, cyp2d6-met was also stu