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Assessment of drug–drug interactions caused by metabolism-dependent cytochrome P450 inhibition

✍ Scribed by Ji-Yoon Lee; Sang Yoon Lee; Soo Jin Oh; Ki Ho Lee; Young Suk Jung; Sang Kyum Kim


Book ID
113518487
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
461 KB
Volume
198
Category
Article
ISSN
0009-2797

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The magnitude of drug±drug interactions in vitro involving competitive inhibition of cytochrome (CYP) isozymes by newer antidepressants can theoretically be shown to be dependent upon several factors. These include the concentration of both the substrate and inhibitor, the anity of the inhibitor for