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Depressed sarcolemal Na+Ca2+ exchange and contractile activity in hearts due to oxygen free radicals

✍ Scribed by Taku Matsubara; Naranjan S Dhalla

Book ID
115984993
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
101 KB
Volume
24
Category
Article
ISSN
0022-2828

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✍ Taku Matsubara; Naranjan S. Dhalla 📂 Article 📅 1996 🏛 Springer 🌐 English ⚖ 581 KB

Although in vitro studies have shown that oxygen free radicals depress the sarcolemmal Ca(2+)-pump activity and thereby may cause the occurrence of intracellular Ca2+ overload for the genesis of contractile failure, the exact relationship between changes in sarcolemmal Ca(2+)-pump activity and cardi