Depletion of serotonin decreases the effects of the kappa-opioid receptor agonist U-69593 on cocaine-stimulated activity
✍ Scribed by Elena Zakharova; Stephanie L. Collins; Maria Åberg; Adarsh Kumar; J.B. Fernandez; Sari Izenwasser
- Book ID
- 113587504
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 291 KB
- Volume
- 586
- Category
- Article
- ISSN
- 0014-2999
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U-69593, the selective -opioid agonist, was repeatedly administered in single daily injections (0.32 mg/kg) to male, Sprague-Dawley rats. Two or ten days later, the rats were euthanized and dopamine D 1 and D 2 receptors were measured using ( 3 H]SCH 23390 or [ 3 H]sulpiride, respectively, in caudat
Reinforcing properties of drugs of abuse are reduced by the coadministration of kappa opioid receptor (KOR) agonists. This effect is related to the inhibition of dopamine (DA) release in the nucleus accumbens (NAc) produced by the acute administration of KOR agonists. The present study was undertake