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Depletion of mitochondrial DNA by ddC in untransformed human cell lines

✍ Scribed by Isabelle Nelson; Michael G. Hanna; Nicholas W. Wood; A. E. Harding


Book ID
110613724
Publisher
Springer
Year
1997
Tongue
English
Weight
546 KB
Volume
23
Category
Article
ISSN
1572-9931

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## Abstract Although the net benefits of tamoxifen in adjuvant breast cancer therapy have been proven, the recurrence of the cancer in an aggressive and hormone independent form has been highly problematic. We previously demonstrated the important role mitochondrial DNA (mtDNA) plays in hormone‐ind