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Depletion of mitochondrial DNA associated with infantile cholestasis and progressive liver fibrosis

✍ Scribed by Pierre-Henri Ducluzeau; Alain Lachaux; Raymonde Bouvier; Nathalie Streichenberger; Georges Stepien; Bénédicte Mousson


Book ID
118568896
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
615 KB
Volume
30
Category
Article
ISSN
0168-8278

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The "D drug" HIV reverse-transcriptase inhibitors zalcitabine, didanosine, and stavudine are relatively strong inhibitors of polymerase-gamma compared with the "non-D drugs" zidovudine, lamivudine, and abacavir. D drugs deplete mitochondrial DNA (mtDNA) in cultured hepatocytes. This mtDNA depletion