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Depletion of CD4 T lymphocytes in human lymphoid tissue infected ex vivo with doxycycline-dependent HIV-1

✍ Scribed by Yana Kiselyeva; Yoshinori Ito; Rosangela G. Lima; Jean-Charles Grivel; Atze T. Das; Ben Berkhout; Leonid B. Margolis

Book ID: 113946055
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 206 KB
Volume: 328
Category: Article
ISSN: 0042-6822
DOI: 10.1016/j.virol.2004.07.014

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## Abstract Human immunodeficiency virus type 1 (HIV‐1) infection is characterized by a progressive decrease of CD4^+^ T cells accompanied by other immune dysfunctions. Telomerase is transiently activated in lymphocytes during activation and is able to compensate for the progressive telomeric loss