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Density-Dependent Inhibition of Growth Involves Prevention of EGF Receptor Activation by E-Cadherin-Mediated Cell–Cell Adhesion

✍ Scribed by Kazuhide Takahashi; Katsuo Suzuki


Book ID
115602430
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
415 KB
Volume
226
Category
Article
ISSN
0014-4827

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The adhesion of tumor cells to various extracellular matrix (ECM) proteins is influenced by epidermal growth factor (EGF). Maximal effects are obtained at low EGF concentrations, at which mostly the cytoskeleton-associated high-affinity EGF receptors (EGFRs) are saturated. Tumor cells expressing EGF