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Denervation enhances spontaneous inflammatory myopathy in SJL mice

✍ Scribed by Margitta T. Kampman; Sylvie Lafond Benestad; Tormod Fladby; Jan Mæhlen

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
602 KB
Volume
22
Category
Article
ISSN
0148-639X

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✦ Synopsis

We studied the effect of denervation on the spontaneous inflammatory myopathy that occurs in SJL mice. Cryosections from innervated and denervated calf muscles were assessed for severity of inflammation, relative proportions of mononuclear cell subsets, and major histocompatibility complex (MHC) class I expression. A significant increase in mononuclear cell infiltrates occurred in the denervated muscle. Denervation also changed the composition of mononuclear cell infiltrates towards a higher percentage of CD8 + T cells (19% versus 11%). MHC class I expression was enhanced in denervated muscle compared with innervated muscle. Our findings indicate that inflammation in muscle may be enhanced by denervation.

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