Dendritic cells modulated by innate immunity improve collagen-induced arthritis and induce regulatory T cells in vivo
✍ Scribed by Olivier Jaen; Sandrine Rullé; Natacha Bessis; Abokouo Zago; Marie-Christophe Boissier; Géraldine Falgarone
- Book ID
- 108782364
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 354 KB
- Volume
- 126
- Category
- Article
- ISSN
- 0019-2805
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Streptococcal cell wall (SCW)-induced arthritis is a chronic, erosive polyarthritis which can be induced in susceptible Lewis rats by one intraperitoneal injection of a sterile, aqueous suspension of SCW. The chronic phase of the disease is dependent on Tcells. Mercuric chloride is an immunomodulati
## Abstract ## Objective To investigate the potential therapeutic action of the immunomodulatory neuropeptide urocortin (UCN) in an experimental model of rheumatoid arthritis (RA). ## Methods After disease onset, DBA/1J mice with collagen‐induced arthritis (CIA) were treated with UCN, and the in