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Dendritic cells expressing BTLA induces CD8+ T cell tolerance and attenuates the severity of diabetes

✍ Scribed by Shufa Li; Min Zhang; Fei Xiang; Jianyong Zhao; Chao Jiang; Jinkun Zhu

Book ID
116964140
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
327 KB
Volume
29
Category
Article
ISSN
0264-410X

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Co-signal receptors provide crucial activating or attenuating signals for T cells. The B and T lymphocyte attenuator (BTLA/CD272) is a third member of co-inhibitory receptors, which belongs to the CD28 immunoglobulin-superfamily. Using monoclonal antibodies (mAbs) against human BTLA, we show that BT