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Dendritic cell tolerogenicity: a key mechanism in immunomodulation by vitamin D receptor agonists

✍ Scribed by Luciano Adorini; Giuseppe Penna

Book ID
116532199
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
910 KB
Volume
70
Category
Article
ISSN
0198-8859

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## Abstract Dendritic cells (DCs) not only induce but also modulate T cell activation. 1,25‐dihydroxyvitamin D~3~ [1,25(OH)~2~D~3~] induces DCs with a tolerogenic phenotype, characterized by decreased expression of CD40, CD80, and CD86 costimulatory molecules, low IL‐12 and enhanced IL‐10 secretion