## Abstract ## BACKGROUND Anecdotal cases of chromosomal abnormalities in Philadelphia chromosome (Ph)βnegative metaphases have been reported in patients with chronic myelogenous leukemia (CML) in the chronic phase during treatment with interferon and, more recently, with imatinib. This phenomenon
Demonstration of Philadelphia chromosome negative abnormal clones in patients with chronic myelogenous leukemia during major cytogenetic responses induced by imatinib mesylate
β Scribed by O'Dwyer, M E; Gatter, K M; Loriaux, M; Druker, B J; Olson, S B; Magenis, R E; Lawce, H; Mauro, M J; Maziarz, R T; Braziel, R M
- Book ID
- 110055396
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 223 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0887-6924
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## Abstract ## BACKGROUND Obtaining a major (Philadelphia chromosome [Ph] of < 35%) or a complete cytogenetic response (Ph of 0%) has been associated with excellent longβterm survival. Cytogenetic response may continue to improve with therapy. Because early allogeneic stem cell transplantation (SC
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