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Demonstration of IL-1α and IL-1β secretion by the monocytic leukemia cell line, THP-1

✍ Scribed by Edwin V. Gaffney; Cheryl R. Stoner; Susan E. Lingenfelter; Lisa A. Wagner

Book ID: 118901592
Publisher: Elsevier Science
Year: 1989
Tongue: English
Weight: 764 KB
Volume: 122
Category: Article
ISSN: 0022-1759
DOI: 10.1016/0022-1759(89)90266-4

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## Abstract A human leukemic cell line (THP‐1) cultured from the blood of a boy with acute monocytic leukemia is described. This cell line had Fc and C3b receptors, but no surface or cytoplasmic immunoglobulins. HLA haplotypes of THP‐1 were HLA‐A2, ‐A9, ‐B5, ‐DRW1 and ‐DRW2. The monocytic nature of