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Demonstration of Feasibility of In Vivo Gene Therapy for Gaucher Disease Using a Chemically Induced Mouse Model

✍ Scribed by Marshall, J

Book ID: 120878762
Publisher: Nature Publishing Group
Year: 2002
Tongue: English
Weight: 287 KB
Volume: 6
Category: Article
ISSN: 1525-0016
DOI: 10.1006/mthe.2002.0650

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## Abstract ## Background Gene‐directed enzyme prodrug therapy (GDEPT) based on the __E. coli__ enzyme purine nucleoside phosphorylase (PNP) represents a new approach for treating slow growing tumours like prostate cancer (PCa). Expressed enzyme converts a systemically administered prodrug, fludar