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Demonstration of an endogenous, competitive inhibitor(s) of [3H] diazepam binding in bovine brain

✍ Scribed by P.J. Marangos; S.M. Paul; P. Greenlaw; F.K. Goodwin; P. Skolnick

Book ID: 118938620
Publisher: Elsevier Science
Year: 1978
Tongue: English
Weight: 361 KB
Volume: 22
Category: Article
ISSN: 0024-3205
DOI: 10.1016/0024-3205(78)90476-9

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Several purines have been shown to be competitive inhibitors of [3H] diazepam binding. Inosine has also been shown to have benzodiazepine-like neurophysiologic, pharmacologic and behavioral effects, and to partially inhibit caffeine-induced seizures in mice. Using presumptive therapeutic doses ofino