Delivery of Oligonucleotides and Analogues: The Oligonucleotide Conjugate-Based Approach
โ Scribed by Fanny Marlin; Philippe Simon; Tula Saison-Behmoaras; Carine Giovannangeli
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 276 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1439-4227
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Successful gene therapy depends on the development of efficient delivery systems. Although pDNA and ODN are novel candidates for nonviral gene therapy, their clinical applications are generally limited owing to their rapid degradation by nucleases in serum and rapid clearance. A great deal of effort
## Dedicated to Prof. Dr. Wolfgang Pfleiderer on the occasion of his 75th birthday Oligodeoxynucleotide conjugates 1 ยฑ 15 carrying anchoring groups such as amino, thiol, pyrrole, and carboxy groups were prepared. A post-synthetic modification protocol was developed. In this method 2'-deoxy-O 4 -(p
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